Huib schnippers biography of albert

  • Albert Einstein, the man who developed the theory of relativity and unlocked the secrets of the atom, had an estimated IQ of 160.
  • My dad was born and grew up in rural Alberta.
  • Albert's.

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    Abstract

    Tumor acidosis is associated with increased invasiveness and drug resistance. Here, we take an unbiased approach to identify vulnerabilities of acid-exposed cancer cells by combining pH-dependent flow cytometry cell sorting from 3D colorectal tumor spheroids and transcriptomic profiling. Besides metabolic rewiring, we identify an increase in tetraploid cell frequency and DNA damage response as consistent hallmarks of acid-exposed cancer cells, supported by the activation of ATM and ATR signaling pathways. We find that regardless of the cell replication error status, both ATM and ATR inhibitors exert preferential growth inhibitory effects on acid-exposed cancer cells. The efficacy of a combination of these drugs with 5-FU is further documented in 3D spheroids as well as in patient-derived colorectal tumor organoids. These data position tumor acidosis as a revelator of the therapeutic potential of DNA repair blockers and as an attractive clinical biomarker to predict the res

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    Director, Zaha Hadid Architects

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    Editor in ledare, ArchDaily

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    Founder, AL_A

     

    Michael Meredith

    Princeton University, MOS

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    Neri&Hu Design and Research Office

    China

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    Partner at Foster + Partners

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    Director, okänt Senseable City Lab

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    Andrew Mason

    Director of Contracts for

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    Key 2017 Accomplishments

    BHA congratulates board member Dr. Lowell Schnipper, Theodore and Evelyn Berenson Professor of Medicine at Harvard Medical School, who obtained two three-year grants of $20,000 per year from the Sartia Kenedy East Foundation to support cervical cancer prevention programs at St. Albert’s and at Karanda Mission Hospitals for 2017-2019.

    Cervical Cancer Prevention

    St. Albert’s Mission Hospital

    As of March 31, 2017: St. Albert’s cervical cancer prevention program had screened nearly 8,900 women; identified more than 400 women with precancerous changes and 98 women with possible cervical cancer. The hospital had performed a total of 135 cryotherapy procedures to prevent the development of the disease. The program began Aug. 1, 2013.

    Karanda Mission Hospital

    Dr. Schnipper obtained a three-year, $20,000 per year grant to support cervical-cancer screening at Karanda Mission Hospital. Our July trip to Zimbabwe (described below) inclu

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